The first Master Class was held in Rolduc, a convent in the southern province of Limburg in the Netherlands, in 1999. This proved to be successful. Eminent professors of different universities in both countries were invited to teach. All accepted and made this Master Class into a wonderful experience for all involved. Meanwhile the collaboration was enlarged. A study trip of teachers and students from Amsterdam and Heidelberg / Heilbronn made contact with the training programs in Minneapolis and Salt Lake City.

In 2000 a successful Master Class took place in Bad Wimpfen, in Germany. Subsequently students presented results of their own work in Hannover, where an international medical informatics conference took place.